Glucose-6-fosifate dehydrogenase (G6PDH)

Glucose 6 fosifate dehydrogenase (G6PD) ibura ni imiterere yumurage aho ingirangingo zamaraso zitukura zisenyuka (hemolysis) mugihe umubiri uhuye nibiryo bimwe na bimwe, ibiyobyabwenge, kwandura cyangwa guhangayika.Bibaho mugihe umuntu yabuze cyangwa afite urugero ruke rwa enzyme glucose-6-fosifate dehydrogenase.Iyi misemburo ifasha selile zitukura gukora neza.Ibimenyetso mugihe cya hemolytike birashobora kuba birimo inkari zijimye, umunaniro, ubunebwe, umuvuduko ukabije wumutima, guhumeka neza, no guhumeka uruhu (jaundice).Ibura rya G6PD ryarazwe mu buryo bwa X buhujwe no kwifata kandi ibimenyetso bikunze kugaragara ku bagabo (cyane cyane Abanyamerika bo muri Afurika ndetse no mu bice bimwe na bimwe bya Afurika, Aziya, na Mediterane).Iterwa nimpinduka zishingiye kuri gen muri G6PD.

Glucose-6-Phophate Dehydrogenase (G-6-PDH) igizwe na subunits ebyiri zuburemere bwa molekile zingana. Urutonde rwa aminide acide ya monomer rwashyizwe ahagaragara.G-6-PDH yakoreshejwe mubushakashatsi bwa nikotinamide adenine dinucleotide na tissue pyridine nucleotide.G-6-PDH irashobora kongera gukora uhereye kubisubizo bya urea.

Glucose 6-fosifate dehydrogenase ni enzyme yingenzi igenga intambwe yambere yinzira ya pentose fosifate.G-6-P-DH oxyde glucose-6- fosifate imbere ya NADP⁺ gutanga umusaruro 6- fosifogluconate.Polyacrylamide gel electrophorei, irangi ryibikorwa, hamwe nubushakashatsi burwanya umusemburo G-6- PDH antibody immunoblotting yerekanye ko G-6-PDH ari glycoproteine.