Gliclazide (21187-98-4)
Urutonde rwibicuruzwa
Gliclazide ni sulfonylurea yo mu kanwa imiti igabanya ubukana.Nifu ya kirisiti yera cyangwa ifu ya kristaline, idafite impumuro nziza kandi itaryoshye.
Gliclazide nigisekuru cya 2 umunwa sulfonylurea hypoglycemic agent hamwe nibikorwa bikomeye.Uburyo bwabwo busa nubwa toluenosulfonylurea, ni ukuvuga, butoranya bukora kuri pancreatic β-selile kugirango buteze imbere insuline kandi bwongere irekurwa rya insuline nyuma yo kurya glucose, idashobora gusa kunoza metabolisme y’abarwayi ba diyabete, ahubwo inatezimbere cyangwa itinda kubaho kwa indwara ya diabete.
Gliclazide ikoreshwa cyane cyane mubwoko bwa diyabete yo mu bwoko bwa II bworoheje kandi butagereranywa hamwe n'abantu bakuze aho imirire no kugenzura imyitozo byonyine bitagira ingaruka kandi nta bushake bwa ketose, kandi binateza imbere ibikomere by'amafaranga hamwe n'imikorere mibi ya metabolike n'imitsi itwara abarwayi ba diyabete.
Gusaba
Gliclazide ikoreshwa muguhashya hyperglycemia muri diabete ya gliclazide yitabirwa na diyabete ihamye, yoroheje, idakunda ketose, diyabete yo mu bwoko bwa 2.Ikoreshwa mugihe diyabete idashobora kugenzurwa no gucunga neza imirire no gukora siporo cyangwa mugihe imiti ivura insuline idakwiye.
| Ikizamini | Ibisobanuro | Ibisubizo by'isesengura |
| Kugaragara | Ifu yera cyangwa hafi yera. | Ifu yera |
| Gukemura | Mubyukuri bidashonga mumazi;gushonga kubuntu muri methylene chloride;gushonga gake muri acetone;gushonga gato muri Ethanol (96 ku ijana). | Yujuje ibisabwa |
| Ibiranga | Imirasire ya infrarafurike ihujwe niyabonetse hamwe na gliclazide CRS. | Yujuje ibisabwa |
| Umwanda B (Na HPLC) | ≤2ppm | 0.5ppm |
| Ibyuma biremereye | ≤10ppm | <10ppm |
| Ibintu bifitanye isano (Na HPLC) | Umwanda F ≤0.1% | Kutamenyekana |
| Buri mwanda utazwi ≤0,10% | 0.04% | |
| Igiteranyo cyumwanda usibye F ≤0.2% | 0.11% | |
| Gutakaza kumisha | ≤0.25% | 0.11% |
| Ivu ryuzuye | ≤0.1% | 0.03% |
| Umuti usigaye (Na GC) | Ethyl acetate NMT 2500 ppm | 265ppm |
| N, N-Dimethylformamide NMT 880 ppm | Kutamenyekana | |
| Suzuma | 99.0-101.0%, ku buryo bwumye. | 100.0% |
| Umwanzuro | Ibisubizo by'ibizamini bihuye na EP8. | |
