Acide Tranexamic (1197-18-8)
Ibisobanuro ku bicuruzwa
Ac Acide ya Tranexamic (1197-18-8)
● URUBANZA No.:·1197-18-8
● EINECS No.: 356.2222
● MF: C8H15NO2
Gupakira: 25Kg / Ingoma
Acide Acide Tranexamic (TXA) ni imiti ikoreshwa mu kuvura cyangwa gukumira gutakaza amaraso menshi biturutse ku ihungabana rikomeye, kuva amaraso nyuma yo kubyara, kubagwa, gukuramo amenyo, kuva amaraso mu mazuru, no mu mihango iremereye. [2] [3]Ikoreshwa kandi kuri hereditori angioedema. [2] [4]Ifatwa mu kanwa cyangwa no guterwa mumitsi.
Uburyo bwibikorwa
Acide ya Tranexamic nikigereranyo cyoguhuza aside aside amine.Ikora nka antifibrinolytike muguhuza bidasubirwaho ibibanza bine byakira lysine kuri plasminogen.Ibi bigabanya ihinduka rya plasminogene na plasmin, birinda kwangirika kwa fibrin no kubungabunga urwego rwimiterere ya matrike ya fibrin. AcideTranexamic ifite inshuro umunani ibikorwa bya antifibrinolytike ya analogue ishaje, ε-aminocaproic aside. ibikorwa bya plasmin ifite imbaraga nke (IC50 = 87 mM), kandi irashobora guhagarika urubuga-rukora rwa urokinase plasminogen ukora (uPA) rufite umwihariko (Ki = 2 mM), imwe murwego rwo hejuru muri proteine zose za serine.
Imikorere ya aside ya tranexamic
Acide Tranexamic ikoreshwa kenshi nyuma y’ihungabana rikomeye.Acide Tranexamic ikoreshwa mu gukumira no kuvura gutakaza amaraso mu bihe bitandukanye, nk'uburyo bw'amenyo, kuva amaraso menshi mu mihango, no kubagwa bifite ibyago byinshi byo gutakaza amaraso.
| Ibintu by'ikizamini | Ibipimo bya farumasi | Ibisubizo by'ibizamini | |
| IMITERERE | Kugaragara: Ifu yera cyangwa hafi yera, ifu ya kristu | Ifu ya kirisiti yera | |
| Gukemura: Kubora neza mumazi no muri acide glacial acetique, muburyo budashobora gushonga muri acetone no muri Ethanol (96%) | Pass | ||
| KUMENYA | Infrared Absorption Spectrophotometry: IR ya IR ihuye na acide ya Tranexamic CRS | Pass | |
| IKIZAMINI | pH (2,2.3) | 7.0 〜8.0 | 7.4 |
| Ibintu bifitanye isano (HPLC2.2.29) | Umwanda A≤ 0.1% | Ntibimenyekana | |
| Umwanda B≤ 0.2% | 0.03% | ||
| ImpuritiesC Umwanda utazwi≤ 0,10% Impanuka D. Ibindi Byanduye | 0.002% 0.001% Ntibimenyekana | ||
| Igiteranyo cyumwanda utazwi≤ 0.2% | 0.003% | ||
| Halides Yerekanwe nka Chloride | 40140ppm | <140ppm | |
| Gutakaza Kuma | ≤0.5% | 0.026% | |
| Ashu | ≤0.1% | 0.027% | |
| ASSAY | Igomba kuba muri (Yumye) 99.0% 〜101.0% | 100.1% | |
